Phentermine works on the hypothalamus portion of the brain to release

Some medicines may interact with phentermine, such as the following:

• Dexfenfluramine, fenfluramine, furazolidone, or MAOIs (e.g., phenelzine) because the risk of serious side effects, such as increasing headache, high blood pressure, slow heart rate, elevated temperature, or possibly fatal lung problems, may be increased
• Guanadrel(Hylorel) or guanethidine(Ismelin) because their effectiveness may be decreased by phentermine
• Antacids: Antacids may decrease the excretion of phentermine.
• Carbonic anhydrase inhibitors (acetazolamide, dichlorphenamide, methazolamide): Carbonic anhydrase inhibitors may decrease the excretion of phentermineIt is approved as an appetite suppressant to help reduce weight in obese patients

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Taking phentermine together with other diet medications such as fenfluramine (Phen-Fen) or dexfenfluramine (Redux) can cause a rare fatal lung disorder called pulmonary hypertension. Do not take phentermine with any other diet medications without your doctor's advice.

Phentermine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol can increase certain side effects of this medicine.